Möller I, Martinez-Puig D, Chetrit C. Oral administration of a natural extract rich in hyaluronic acid for the treatment of knee OA with synovitis: a retrospective cohort study. Clinical Nutrition Supplements 2009;4(2):171-172

Martinez-Puig D, Möller I, Fernández C, Chetrit C. Efficacy of oral administration of yoghurt supplemented with a preparation containing hyaluronic acid (Mobilee™) in adults with mild joint discomfort: a randomized, double-blind, placebo controlled intervention study. Mediterranean Journal of Nutrition and Metabolism 2013;6:63–68.

Solà R, Valls RM, Martorell I, Giralt M, Pedret A, Taltavull N, Romeu M, Rodríguez À, Moriña D, Lopez de Frutos V, Montero M, Casajuana MC, Pérez L, Faba J, Bernal G, Astilleros A, González R, Puiggrós F, Arola L, Chetrit C, Martinez-Puig D. A low-fat yoghurt supplemented with a rooster comb extract on muscle joint function in adults with mild knee pain: a randomized, double blind, parallel, placebo-controlled, clinical trial of efficacy. Food Funct. 2015 Nov;6(11):3531-9.

The results of the present study suggest that Mobilee® intake strongly inhibits synovial effusion and reduces knee pain. It has been demonstrated that synovial effusion is an independent risk factor for OA, and it correlates with faster cartilage degradation. Therefore, the reduction of synovial effusion demonstrated as a result of Mobilee® treatment may delay OA progression.

Results of this pilot clinical trial suggest that daily supplementation with Mobilee® at a dose of 80mg/day during 8 weeks may decrease pain, improve physical function and enhance several aspects of quality of life in subjects with knee osteoarthritis.

Long-term consumption of a low-fat dairy product supplemented with Mobilee® improves muscle function suggesting lower pain and a better performance of the flexor and extensor muscles of the affected knee, thus providing new dietary therapeutic perspectives.

Sánchez J, Bonet ML, Keijer J, van Schothorst EM, Mölller I, Chetrit C, Martinez-Puig D, Palou A. Blood cells transcriptomics as source of potential biomarkers of articular health improvement: effects of oral intake of a rooster combs extract rich in hyaluronic acid. Genes Nutr. 2014 Sep;9(5):417.

This prospective placebo-controlled nutritional study confirmed that 3 months of intake of a natural product containing Mobilee® in healthy individuals with knee discomfort reduces pain and joint effusion, and provides improvements in muscle strength in those patients without joint effusion. Genes related to GAG metabolism and extracellular matrix dynamics are differentially expressed in blood cells between the supplement and placebo groups post-intervention, and the expression of some of these genes correlates with indicators of articular pain and muscular strength.

Martinez-Puig D, Möller I, Fernández C, Chetrit C. Efficacy of oral administration of yoghurt supplemented with a preparation containing hyaluronic acid (Mobilee™) in adults with mild joint discomfort: a randomized, double-blind, placebo controlled intervention study. Mediterranean Journal of Nutrition and Metabolism 2013;6:63–68

Taken together, these results show that oral supplementation whith Mobilee® improves joint mechanics ans muscle function as determined through isokinetic testing, thus attenuating risk factors of OA.

Moriña D, Solà R, Valls RM, López de Frutos V, Montero M, Giralt M, Papell I, Bernal G, Faba J, Casajuana C, Rodríguez A, Chetrit C, Martinez-Puig, D. Efficacy of a Low-fat Yogurt Supplemented with a Rooster Comb Extract on Joint Function in Mild Knee Pain Patients: A Subject-level Meta-analysis. Annals of Nutrition and Metabolism 2013;63(S1):1386

Long-term consumption of low-fat dairy products supplemented with Mobilee® improves muscle function, synovial effusion and reduces pain, providing clinical benefit for healthy people with mild knee pain. These results support the use of Mobilee® to reduce the risk and progressionof osteoarthritis.

Torrent A, Ruhí R, Martínez C, Castells G, Castellarnau-Castellà C. Anti-inflammatory activity and absorption of a natural rooster comb extract (Mobilee®). Osteoarthritis and Cartilage 2010;18(S2):S246-S247.

Torrent A, Ruhí R, Martínez C, Castells G, Castellarnau-Castellà C. Anti-inflammatory activity and absorp- tion of a natural rooster comb extract (Mobilee®). Osteoarthritis and Cartilage 2010;18(S2):S246-S247Pages S246-S247.

Torrent A, Ruhí R, Theodosakis J, Blanco FJ. Comparative efficacy of IB0004, extracted hyaluronic acid (HA) and fermented HA on the synthesis of endogenous ha by human synoviocytes. Osteoarthritis and Cartilage 2009;17(S1):S278-S279

From the results obtained, it can be affirmed that Mobilee® is absorbed through the intestinal mucous membrane. Absorption takes place chiefly in the duodenum, and subsequently in the jejunum and ileum.

These results indicate that Mobilee® may have anti-inflammatory and chondroprotective effects.

Based on the results obtained, it can be affirmed that Mobilee® increases synthesis of HA. This increase would apparently be followed by HA secretion into the extracellular space. Therefore, Mobilee® may stimulate HA secretion to synovial fluid and consequently improve joint function and patients’ quality of life. This mechanism of action may explain part of the product’s effectiveness.

Torrent A, Ruhí, R, Theodosakis J, Blanco FJ. Comparative efficacy of IB0004, extracted hyaluronic acid (HA) and fermented HA on the synthesis of endogenous ha by human synoviocytes. Osteoarthritis and Cartilage 2009;17(S1):S278-S279 horas de incubación.

Based on the results obtained, it can be stated that, at the same concentration levels of each product, the highest levels of endogenous HA were measured in the cells stimulated with Mobilee® According to this study, it can be concluded that there are differences between the action of Mobilee® and HA from bacterial fermentation in the synovial-fluid cells, with Mobilee® being more active in promoting synthesis of endogenous HA.

Castillo V, Bendele AM, Li K, Martinez-Puig D, Turner SM, Chetrit C. Effects of oral administration of Hyal- Joint® in 17 day rat developing type II collagen arthritis. Osteoarthritis and Cartilage 2010;18(S2):S244-S245

Our results suggest that the use of Mobilee® for the management of developing type II collagen arthritis in rats is safe and effective, having beneficial effects on the histopathology parameters in ankles and knees.

Martinez-Puig D, Carmona JU, Arguelles D, Deulofeu R, Ubia A, Prades M. Oral hyaluronic acid administration improves osteochondrosis clinical symptoms and slightly increases intra-articular concentration of hyaluronic acid in a horse model: a pilot survey. Osteoarthritis and Cartilage 2007;15(S3):C62-C63

The overall results suggest that oral Mobilee® administration could increase HA concentration, wich could also be related to improvements in the clinical condition of the affected joint.

Ref: Torrent et al. The FASEB Journal 2015, Vol. 29 no. 1 Supplement 737.4

The aim of this study was to investigate the therapeutic potential of Mobilee®, a rooster comb extract with a high concentration of hyaluronic acid, other polysaccharides and collagen, to combat muscle atrophy and sarcopenia.